{"id":26224,"date":"2026-08-07T14:26:21","date_gmt":"2026-08-07T14:26:21","guid":{"rendered":"https:\/\/cehhs.utk.edu\/krss-dev\/?page_id=26224"},"modified":"2026-10-02T14:01:04","modified_gmt":"2026-10-02T14:01:04","slug":"the-active-change-laboratory","status":"publish","type":"page","link":"https:\/\/cehhs.utk.edu\/krss\/research\/the-active-change-laboratory\/","title":{"rendered":"The Active Change Laboratory"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fw__grey--box hero__clr--stripe is-layout-constrained wp-block-group-is-layout-constrained\">\n<figure class=\"wp-block-image alignfull size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"2250\" height=\"922\" src=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/10\/lab-photo-2250w.webp\" alt=\"Research laboratory with workbenches, computers and lab equipment\" class=\"wp-image-26883\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/10\/lab-photo-2250w.webp 2250w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/10\/lab-photo-2250w-300x123.webp 300w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/10\/lab-photo-2250w-1024x420.webp 1024w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/10\/lab-photo-2250w-768x315.webp 768w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/10\/lab-photo-2250w-1536x629.webp 1536w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/10\/lab-photo-2250w-2048x839.webp 2048w\" sizes=\"auto, (max-width: 2250px) 100vw, 2250px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-columns alignwide content-block is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-smokey-x-background-color has-background is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading has-white-color has-text-color\"><em>THE ACTIVE CHANGE<\/em><\/h3>\n\n\n\n<h2 class=\"wp-block-heading has-white-color has-text-color\"><strong>LABORATORY<\/strong><\/h2>\n\n\n\n<p class=\"has-white-color has-text-color wp-block-paragraph\"><em>Advancing Health Outcomes through Community Engagement and Optimization of Lifestyle Interventions<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull tab-box has-light-background-color has-background is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns alignwide tab-box__rw is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-list tab-box__list\">\n<li><a href=\"#people\">Our People<\/a><\/li>\n\n\n\n<li><a href=\"#facilities\">Facilities &amp; Equipment<\/a><\/li>\n\n\n\n<li><a href=\"#future\">Future Students<\/a><\/li>\n\n\n\n<li><a href=\"#contributions\">Contributions to Science<\/a><\/li>\n\n\n\n<li><a href=\"#publications\">Publications<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Goal:<\/strong> Engage research partners at multiple levels (community member, provider, organizational leader) in the design and optimization of lifestyle interventions to improve sustained behavior change.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mission:<\/strong> Our mission is to help all individuals improve their health and wellbeing by changing their lifestyle habits (physical activity and nutrition) to prevent the many chronic diseases that are associated with unhealthy lifestyles such as obesity, cardiovascular disease, cancer, and Diabetes. We want to design and optimize interventions such that patients want to participate in them, providers can feasibly deliver them, and organizational leaders want to adopt them. We focus on designing for implementation and sustainability from the beginning.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>State-of-the Art Research Lab Space:<\/strong> The Ostendorf lab is housed in the University of Tennessee\u2019s <a href=\"https:\/\/news.utk.edu\/2025\/09\/04\/ut-and-utmc-pursue-scientific-breakthroughs-community-impact-in-center-for-precision-health\/\">Center for Precision Health<\/a> (CPH), a state-of-the art, collaborative research facility located at UT Research Park at Cherokee Farm, 1600 Accelerator Way.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<h2 id=\"people\" class=\"wp-block-heading\">Our People<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Study Coordinators<\/h4>\n\n\n\n<div style=\"height:4rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group profileCardContainer is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileCard is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileHeadshot is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"600\" src=\"http:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture2-1.jpg\" alt=\"Alex Manis\" class=\"wp-image-26257\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture2-1.jpg 400w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture2-1-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileInfo is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading profileName\">Alex Manis, BS<\/h3>\n\n\n\n<p class=\"profileTitle wp-block-paragraph\">University of Tennessee Knoxville<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileCard is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileHeadshot is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"600\" src=\"http:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture3-1.jpg\" alt=\"Chloe Simpson\" class=\"wp-image-26258\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture3-1.jpg 400w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture3-1-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileInfo is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading profileName\">Chloe Simpson, BA<\/h3>\n\n\n\n<p class=\"profileTitle wp-block-paragraph\">University of Colorado Anschutz Medical Campus<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileCard is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileHeadshot is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"600\" src=\"http:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture4-1.jpg\" alt=\"Cristina Rebellon\" class=\"wp-image-26259\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture4-1.jpg 400w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture4-1-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileInfo is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading profileName\">Cristina Rebellon, RD<\/h3>\n\n\n\n<p class=\"profileTitle wp-block-paragraph\">University of Colorado Anschutz Medical Campus<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Research Assistants<\/h4>\n\n\n\n<div style=\"height:4rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group profileCardContainer is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileCard is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileHeadshot is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"600\" src=\"http:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture5-1.jpg\" alt=\"Evan Griego\" class=\"wp-image-26260\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture5-1.jpg 400w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture5-1-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileInfo is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading profileName\">Evan Griego, BS<\/h3>\n\n\n\n<p class=\"profileTitle wp-block-paragraph\">University of Colorado Anschutz Medical Campus<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Student Research Assistants<\/h4>\n\n\n\n<div style=\"height:4rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group profileCardContainer is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileCard is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileHeadshot is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"600\" src=\"http:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture7-1.jpg\" alt=\"Katie Smith\" class=\"wp-image-26262\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture7-1.jpg 400w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture7-1-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileInfo is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading profileName\">Katie Smith, MS Student<\/h3>\n\n\n\n<p class=\"profileTitle wp-block-paragraph\">University of Tennessee Knoxville<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileCard is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileHeadshot is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"600\" src=\"http:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture8-1.jpg\" alt=\"Payton Riddle\" class=\"wp-image-26263\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture8-1.jpg 400w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture8-1-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileInfo is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading profileName\">Payton Riddle, BS Student<\/h3>\n\n\n\n<p class=\"profileTitle wp-block-paragraph\">University of Tennessee Knoxville<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 id=\"facilities\" class=\"wp-block-heading\">Facilities and Equipment<\/h2>\n\n\n\n<figure class=\"wp-block-image alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"382\" height=\"224\" src=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture11.png\" alt=\"Exterior of the University of Tennessee Medical Center Orthopaedic Institute building\" class=\"wp-image-26266\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture11.png 382w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture11-300x176.png 300w\" sizes=\"auto, (max-width: 382px) 100vw, 382px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>Ostendorf ActiveChange Laboratory <\/strong>is housed on the 3<sup>rd<\/sup> floor of the University Orthopedic Surgery Center within a new, state-of-the-art, collaborative research facility \u2013 The Center for Precision Health (<strong>CPH<\/strong>) \u2013 on the University of Tennessee\u2019s Cherokee Farm Research Park. The CPH is a transdisciplinary research and innovation hub, comprising approximately 12,000 sq ft of space. The overarching concept of the Center is designed to encourage transdisciplinary interaction and collaboration, promote student and postdoc interactions, and generate an atmosphere of education, research, and outreach in the areas of health and medicine.<\/p>\n\n\n\n<div style=\"height:31px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>In brief, the CPH houses:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"421\" height=\"221\" src=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture12.png\" alt=\"Conference room with a large display wall and orange accent wall\" class=\"wp-image-26268\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture12.png 421w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture12-300x157.png 300w\" sizes=\"auto, (max-width: 421px) 100vw, 421px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A private, data visualization room for testing Mobile Applications and conducting focus groups;<\/li>\n\n\n\n<li>Bench (wet-lab) space for 12 scientists;<\/li>\n\n\n\n<li>A cleanroom (e.g., good manufacturing practice) space for analytical and 3D-printing of biomaterials;<\/li>\n\n\n\n<li>Analytical instrumentation facilities, including liquid handling, microscopy, and centrifugation;<\/li>\n\n\n\n<li>Clinical (i.e., patient engagement) space for confidential patient interactions, including 4 private exam<\/li>\n\n\n\n<li>rooms and a phlebotomy space;<\/li>\n\n\n\n<li>Adjacent exercise physiology space (ca. 500 sq ft) for physical therapy, group exercise classes, and mobility evaluations;<\/li>\n\n\n\n<li>Adjacent office, interaction space, and conference rooms;<\/li>\n\n\n\n<li>Four general areas of practice are supported: clinical, computational, orthopedic innovation, and<\/li>\n\n\n\n<li>industry\/entrepreneurial engagement;<\/li>\n\n\n\n<li>PI offices (16) are approximately 100 sq ft, located adjacent to the areas of practice;<\/li>\n\n\n\n<li>Office spaces and workstations for students and postdocs (up to 40, total) are located within the Center;<\/li>\n\n\n\n<li>High-capacity computing capabilities, data visualization, secure servers, and highspeed access to UT\u2019s<\/li>\n\n\n\n<li>secure enclave;<\/li>\n\n\n\n<li>Numerous interaction spaces for collaboration and discussion.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"448\" height=\"306\" src=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture13.png\" alt=\"Open collaboration space with orange accents and people talking\" class=\"wp-image-26269\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture13.png 448w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/Picture13-300x205.png 300w\" sizes=\"auto, (max-width: 448px) 100vw, 448px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Ostendorf\u2019s office is located within the patient engagement and clinical space of the Center. The office for Dr. Ostendorf\u2019s Research Assistant (RA), Alex Manis, is also located at CPH.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Equipment<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Specific equipment available in the ActiveChange Laboratory includes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Activity monitoring: activPAL devices and physical activity questionnaires;<\/li>\n\n\n\n<li>-80\u00baC Freezer, Refrigerator (to store blood and stool samples);<\/li>\n\n\n\n<li>Stadiometer to assess height;<\/li>\n\n\n\n<li>Automatic blood pressure cuff to assess systolic and diastolic blood pressure;<\/li>\n\n\n\n<li>Steps, risers, and stopwatches to conduct the YMCA 3-minute step test;<\/li>\n\n\n\n<li>Participant research supplies (pregnancy tests, urine hats, gloves, etc.)<\/li>\n<\/ul>\n\n\n\n<h2 id=\"future\" class=\"wp-block-heading\">Future Students<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Graduate Students<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The ActiveChange Laboratory is always looking for passionate, well-qualified graduate students interested in the design and optimization of physical activity interventions to prevent chronic diseases (Obesity, Diabetes, Cardiovascular Disease, Cancer). Specifically, the ActiveChange Laboratory concentrates on the use of community-engaged research methods and dissemination and implementation (<strong>D&amp;I<\/strong>) science to guide the design of lifestyle interventions to prevent chronic diseases. The ActiveChange Laboratory applies several theories, models and frameworks to guide the conduct of rigorous science including, but not limited to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Multiphase Optimization Strategy (<strong>MOST<\/strong>) to guide <a href=\"https:\/\/cadio.org\/\">optimization of interventions<\/a>;<\/li>\n\n\n\n<li><a href=\"https:\/\/selfdeterminationtheory.org\/theory\/\">Self-Determination Theory<\/a> (<strong>SDT<\/strong>) to guide development of interventions to support autonomous motivation for behavior change<\/li>\n\n\n\n<li>Reach, Effectiveness, Adoption, Implementation and Maintenance (<a href=\"https:\/\/re-aim.org\/\">RE-AIM<\/a>) to design with dissemination and implementation in mind from the beginning<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Prospective graduate students may apply for a Master\u2019s Degree or PhD in Kinesiology, with a <a href=\"https:\/\/cehhs.utk.edu\/krss\/academics\/graduate-academics\/kinesiology-and-sport-studies-doctoral-programs\/\">concentration in Physical Activity Epidemiology<\/a>. Inquiries about open positions are best directed to Dr. Danielle Ostendorf, the director of the ActiveChange Laboratory. Teaching and research assistantships are available for well-qualified students and the graduate curriculum can be adjusted to fit the goals, needs, and future career direction of the student.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Undergraduate Students<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Undergraduate students interested in completing research within the field of physical activity epidemiology are advised to contact Dr. Danielle Ostendorf for information regarding research opportunities within the ActiveChange Laboratory. ActiveChange Laboratory requires undergraduate students to commit to at least one semester within the laboratory. However, longer commitments to the lab are favored.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Undergraduate students brought on as an assistant within the ActiveChange Laboratory will aid in ongoing research projects and are encouraged to develop their own research ideas. Students who engage in more than one semester of research are also encouraged to present the research in which they become involved at both internal and external research exhibits and professional conferences.<\/p>\n\n\n\n<h2 id=\"contributions\" class=\"wp-block-heading\">Contributions to Science<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Application of Dissemination &amp; Implementation (D&amp;I) Science and Human-Centered Design Testing to Develop Lifestyle Interventions: <\/strong>As an investigator trained in D&amp;I methods, Dr. Ostendorf collaborates with several researchers to aid in the application of D&amp;I models\/theories\/frameworks, D&amp;I methods (including mixed methods), and community-engaged human-centered design testing to their grant proposals. Dr. Ostendorf is a graduate student of the University of Colorado Adult &amp; Child Consortium for Health Outcomes Research &amp; Delivery Science (ACCORDS) graduate certificate program in D&amp;I, thus, has received rigorous training in D&amp;I science. She has completed D&amp;I courses in design for dissemination and sustainability (CLSC 6750), mixed methods (CLSC 6560), D&amp;I grant writing (CLSC 6770), and advanced D&amp;I research topics (CLSC 6850), among others. Dr. Ostendorf is passionate about designing and disseminating lifestyle interventions that not only help adults adopt healthy behaviors but sustain those behaviors long-term. She has published several manuscripts in this area and has also been invited to speak on this topic for national webinars.<\/li>\n<\/ol>\n\n\n\n<ol start=\"2\" class=\"wp-block-list\">\n<li><strong>Sustained Physical Activity Adherence<\/strong>: Dr. Ostendorf\u2019s passion for studying physical activity (<strong>PA<\/strong>) adherence began as a graduate student at the Indiana University of Pennsylvania, where she conducted her first, randomized controlled pilot study for her Master\u2019s Thesis. This study was designed to examine whether the addition of a lifestyle intervention (behavioral and cognitive strategies) to personal training sessions improved exercise adherence and PA behavior over an 8-week period. Participants included 32 healthy adults who volunteered to receive personal training sessions from an exercise science undergraduate student. The results from this study support the use of specific intervention components such as goal setting and self-monitoring to improve exercise adherence. During her doctoral training, Dr. Ostendorf witnessed firsthand the struggle that participants experienced in maintaining the high levels of PA that are critical for long-term weight loss. This experience sparked her research interest in discovering ways to help adults adhere to our PA guidelines and reduce sitting, by focusing on psychosocial and behavioral aspects such as motivation and enjoyment. For her dissertation, Dr. Ostendorf wanted to understand how different motives for PA coexist within an individual using Self-Determination Theory (<strong>SDT<\/strong>). Using a latent profile analysis, she found that at baseline, both controlled motives (i.e. exercise for an external reward such as social recognition, or to avoid guilt) and autonomous motives (i.e. exercise is consistent with values or enjoyable) may help individuals achieve high levels of PA. However, after 6 months of a supervised exercise intervention, only autonomous motives were beneficial for sustaining high levels of PA long-term (12 months later). In addition, adults with high levels of intrinsic regulation achieved high levels of PA long-term, regardless of their levels of the other types of motivation. These data demonstrate the need to design PA interventions that focus on eliciting intrinsically motivating goals.<\/li>\n<\/ol>\n\n\n\n<ol start=\"3\" class=\"wp-block-list\">\n<li><strong>Novel Behavioral Weight Loss Interventions Targeting Reducing Energy Intake and Increasing Physical Activity:<\/strong> Ostendorf received extensive, direct training in implementing large (n = 150-170), randomized, novel, interventional weight loss trials (R01 DK097266, R01 DK111622) through predoctoral and postdoctoral training with Dr. Vicotria Catenacci at the University of Colorado. R01 DK097266 was an 18-month randomized trial designed to determine the optimal time to begin exercise within a comprehensive, behavioral weight loss program. Dr. Ostendorf has several publications in this area of research.<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\">Highlighted Research Funding<\/h3>\n\n\n\n<figure class=\"wp-block-table is-style-regular\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Title and Grant #<\/strong><\/td><td><strong>Major Goals<\/strong><\/td><td><strong>Name of PI<\/strong><\/td><td><strong>Source of Support<\/strong><\/td><td><strong>Total Award Amount<\/strong><\/td><td><strong>Links<\/strong><\/td><\/tr><tr><td>Designing with Dissemination in Mind: Development and Evaluation of a Theory-Based Physical Activity Intervention using the Multiphase Optimization Strategy<br>K01 HL161417<\/td><td>The overall objective of this K01 Career Development Award is to refine and pilot test a theory-based, multilevel physical activity support program (called <em>Move+<\/em>) designed to enhance motivation in adults with overweight or obesity enrolled in a lifestyle weight management program.<\/td><td>Danielle Ostendorf, PhD<\/td><td>NIH, National Heart, Lung, and Blood Institute (NHLBI)<\/td><td>$830,923<\/td><td><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06116435\">Clincialtrials.gov page<\/a> and <a href=\"https:\/\/reporter.nih.gov\/search\/tQtNWBtAYkyJLUTWilOu9g\/project-details\/11286326\">NIH Reporter Page<\/a><\/td><\/tr><tr><td><em>Mov\u00e1monos<\/em>: Translation and Cultural Adaptation of a Theory-Based Physical Activity Support Program for Spanish-Speaking Adults<\/td><td>The overall objective is to translate and culturally adapt an existing physical activity (PA) support program called Move, to create Movamonos (translates to \u201cLet\u2019s move\u201d) by engaging Spanish-speaking co-designers (Aim 1) and then pilot test Movamonos in a single-arm field trial (Aim 2). Consistent with Designing for Dissemination and Sustainability (D4DS) and Equity methods, two frameworks will be integrated to guide the approach: 1) the Multiphase Optimization Strategy (MOST), and 2) the Practical Robust Implementation and Sustainability Model (PRISM).<\/td><td>Danielle Ostendorf, PhD<\/td><td>Colorado Nutrition Obesity Research Center (NORC) Pilot<\/td><td>$40,000<\/td><td><\/td><\/tr><tr><td>Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone with Cognitive Decline<\/td><td><\/td><td>Zan Gao, PhD (<strong>Dr. Ostendorf\u2019s Role: <\/strong>Co-I)<\/td><td>Arizona State University (ASU) Roybal Center<\/td><td>$150,000<\/td><td><\/td><\/tr><tr><td>Novel dietary interventions for reducing obesity-associated breast cancer<br>R01 CA258766<\/td><td>This work will establish whether a subtype of cancer-associated fibroblasts (pCAF) are a novel mechanism by which obesity enhances the survival, growth, and progression of breast cancer and establish whether this mediator is modifiable by the highly novel dietary interventions of intermittent energy restriction induced weight loss.<\/td><td>Paul MacLean, Phd; Victoria Catenacci, MD; Peter Kabos, MD) (<strong>Dr. Ostendorf\u2019s Role:<\/strong> Co-I)<\/td><td>NIH, National Cancer Institute (NCI)<\/td><td>$3,166,683.00<\/td><td><a href=\"https:\/\/reporter.nih.gov\/search\/zcoRRrwb3UGXv6djY8wUKg\/project-details\/11007239\">NIH Reporter<\/a><\/td><\/tr><tr><td>Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation<br>R01 CA242745<\/td><td>The purpose of the study is to prepare to scale up Moving Forward Together (MFT) by adapting a validated web platform (Mentor1to1\u2122). After the adaptation of Mentor1to1TM (thereby creating webMFT), we will use a randomized controlled design to test the intervention (webMFT vs. MVAP tracking) and use mixed method approaches to collect data at the level of coach, survivor, and organization to position our team for a subsequent large-scale pragmatic implementation trial.<\/td><td>Bernardine Pinto, PhD (<strong>Dr. Ostendorf\u2019s Role: <\/strong>Site PI and Consultant)<\/td><td>NIH, National Cancer Institute (NCI)<\/td><td>$4,012,488<\/td><td><a href=\"https:\/\/reporter.nih.gov\/search\/gSAw2R9jWEaBktvf9Aj_lA\/project-details\/11019721\">NIH Reporter<\/a><\/td><\/tr><tr><td>Measuring co-creation during the engagement process in research: A pathway forward<\/td><td>This proposal will develop a pragmatic measure to assess the co-creation process, which is a critical process in stakeholder engagement. The measure will be based on a conceptual model of co-creation and prior work by the study team to define the domains of co-creation and specific activities that support each domain.<\/td><td>Monica Perez-Jolles, PhD (<strong>Dr. Ostendorf\u2019s Role: <\/strong>Co-I and Consultant)<\/td><td>Patient-Centered Outcomes Research Institute (PCORI)<\/td><td>$710,000<\/td><td><\/td><\/tr><tr><td>Effects of allowing choice of dietary regimen within an intensive lifestyle intervention among adults with prediabetes living in rural communities: a pilot and feasibility study<br>ADA 7-22-JDFN-24<\/td><td>The specific aims of this study are to: 1) Engage stakeholders at multiple levels to guide the design of a 16-week PreventT2 + Choice intervention in adults with prediabetes living in rural communities; and 2) Assess the feasibility and acceptability of PreventT2 + Choice intervention.<\/td><td>Elizabeth Thomas, MD (<strong>Dr. Ostendorf\u2019s Role: <\/strong>Co-I and Consultant)<\/td><td>American Diabetes Association (ADA)<\/td><td>$295,176<\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 id=\"publications\" class=\"wp-block-heading\">Featured Publications and News Articles<\/h2>\n\n\n\n<div style=\"height:2vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-63375db1 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1zMbY_sMhYpQ7\/bibliography\/public\/\" target=\"_blank\" rel=\"noreferrer noopener\">Complete List of Published Work<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:2vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Featured Publications:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Catenacci VA*, <strong>Ostendorf DM*<\/strong>, Pan Z, Grau L, Creasy SA, Zaman A, Caldwell AE, Dahle J, Swanson B, Breit MJ, Bing K, Wayland LT, Panter, S, Scorsone JJ, Bessesen DH, MacLean P, and Melanson EL (2025). The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months: A Randomized Clinical Trial; <em>Ann Intern Med<\/em>. 2025 Apr 1; [e-pub]. doi: <a href=\"https:\/\/www.acpjournals.org\/doi\/10.7326\/ANNALS-24-01631\">7326\/ANNALS-24-01631<\/a>.<\/li>\n\n\n\n<li><strong>Ostendorf DM*,<\/strong> Huebschmann AG*, Kindred M, Wickersham K, and Pinto BM (2025). Adopting and implementing an efficacious peer-delivered physical activity program for web platform delivery in survivors of cancer: Organizational readiness and perspectives. Transl Behav Med. 2025 Jan 16;15(1):ibaf051. doi: 10.1093\/tbm\/ibaf051. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41005365\/\">41005365<\/a>.<\/li>\n\n\n\n<li><strong>Ostendorf DM<\/strong>, Schmiege SJ, Conroy DE, Phelan S, Bryan AD, Catenacci VA. Motivational profiles and change in physical activity during a weight loss intervention: A secondary data analysis. <em>Int J Behav Nutr and Phys Act<\/em>. 2021;18(1):158. DOI: <a href=\"https:\/\/ijbnpa.biomedcentral.com\/articles\/10.1186\/s12966-021-01225-5\">1186\/s12966-021-01225-5<\/a>.<\/li>\n\n\n\n<li>Pinto BM, Kindred M, Dunsiger S, Mitchell S, Patel A, <strong>Ostendorf DM<\/strong>, and Huebschmann AG. Effects of web platform delivery of a physical activity program for breast cancer survivors: A randomized controlled trial. Journal of Cancer Survivorship. J Cancer Surviv (2025). <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11764-025-01811-7\">https:\/\/link.springer.com\/article\/10.1007\/s11764-025-01811-7<\/a><\/li>\n\n\n\n<li>Perez Jolles M, Willging, C, Tufte, J, <strong>Ostendorf DM<\/strong>, Kwan BM, Sevick C, Holliman D, and Weiner B (2024). Development and validation of a pragmatic measure of co-creation in research engagement: A study protocol. BMJ Open;14:e091966. doi: <a href=\"https:\/\/bmjopen.bmj.com\/content\/14\/12\/e091966\">1136\/bmjopen-2024-091966<\/a>.<\/li>\n\n\n\n<li>Catenacci VA*, <strong>Ostendorf DM<\/strong>*, Pan Z, Bing K, Wayland LT, Seyoum E, Stauffer BL, Phelan S, Creasy SA, Caldwell AE, Wyatt HR, Bessesen DH, and Melanson EL. (2019). The Impact of Timing of Exercise Initiation on Weight Loss: An 18-Month Randomized Clinical Trial. <em>Obesity<\/em>. 00(0):1-11. PubMed PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31565869\/#:~:text=Conclusions%3A%20Both%20immediate%20and%20delayed,personalized%20based%20on%20patient%20preference.\">31565869<\/a>. *These authors contributed equally to this work.<\/li>\n\n\n\n<li><strong>Ostendorf DM<\/strong>*, Caldwell AE*, Zaman A, Pan Z, Bing K, Wayland LT, Creasy SA, Bessesen DH, MacLean P, Melanson EL, and Catenacci VA (2022). Comparison of weight loss induced by Daily Caloric Restriction versus Intermittent Fasting (DRIFT) in individuals with obesity: Study protocol for a 12-month randomized clinical trial. Trials 23, 718. <a href=\"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-022-06523-2\">https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-022-06523-2<\/a>; *These authors contributed equally to this work.<\/li>\n\n\n\n<li><strong>Ostendorf DM<\/strong>, Blankenship J, Grau L, Arbet J, Mitchell N, Creasy S, Caldwell A, Melanson E, Phelan S, Bessesen D, Catenacci V. (2021). Predictors of long-term weight loss trajectories during a behavioral weight loss intervention: An exploratory analysis. <em>Obesity Science &amp; Practice<\/em>. DOI: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/osp4.530\">1002\/osp4.530<\/a>. *These authors contributed equally to this work.<\/li>\n\n\n\n<li><strong>Ostendorf DM<\/strong>, Lyden K, Pan Z, Wyatt HR, Hill JO, Melanson EL, and Catenacci VA. (2018). Objectively measured physical activity and sedentary behavior in successful weight loss maintainers. <em>Obesity<\/em>. Jan;26(1):53-60. PubMed PMID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29090513\/\">29090513<\/a>.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Featured News Articles:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.cbsnews.com\/video\/can-intermittent-fasting-help-you-lose-more-weight-heres-what-a-new-study-says\/\">https:\/\/www.cbsnews.com\/video\/can-intermittent-fasting-help-you-lose-more-weight-heres-what-a-new-study-says\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.healio.com\/endocrinology\/obesity\/news\/online\/%7B301bf3da-43d4-4c35-a1f5-d93a3dfb0ecf%7D\/baseline-fitness-level-may-predict-future-weight-loss-success\">https:\/\/www.healio.com\/endocrinology\/obesity\/news\/online\/%7B301bf3da-43d4-4c35-a1f5-d93a3dfb0ecf%7D\/baseline-fitness-level-may-predict-future-weight-loss-success<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/coach.nine.com.au\/2019\/04\/09\/11\/57\/diet-exercise-physical-activity-weight-loss-maintenance\">https:\/\/coach.nine.com.au\/2019\/04\/09\/11\/57\/diet-exercise-physical-activity-weight-loss-maintenance<\/a><\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Contact Us<\/h2>\n\n\n\n<div style=\"height:19px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group profileCardContainer is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileCard is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group profileHeadshot is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/exec-cc0d47b7-dd70-4162-b451-fbc857950e15-683x1024.png\" alt=\"Danielle Ostendorf, PhD\" class=\"wp-image-26287\" srcset=\"https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/exec-cc0d47b7-dd70-4162-b451-fbc857950e15-683x1024.png 683w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/exec-cc0d47b7-dd70-4162-b451-fbc857950e15-200x300.png 200w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/exec-cc0d47b7-dd70-4162-b451-fbc857950e15-768x1152.png 768w, https:\/\/cehhs.utk.edu\/krss\/wp-content\/uploads\/sites\/29\/2026\/08\/exec-cc0d47b7-dd70-4162-b451-fbc857950e15.png 1024w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group profileInfo is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading profileName\">Danielle Ostendorf, PhD<\/h3>\n\n\n\n<p class=\"profileTitle wp-block-paragraph\">Assistant Professor, Physical Activity Epidemiology<br>Department of Kinesiology, Recreation, and Sports Studies<br>University of Tennessee Knoxville<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Address: Center for Precision Health, CPH 393<br>1600 Accelerator Way, Suite 300<br>Knoxville, TN 37920<br>Phone: 865-974-8606<\/p>\n\n\n\n<p class=\"fancyLink wp-block-paragraph\"><a href=\"mailto:dostendo@utk.edu\">dostendo@utk.edu<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:5vw\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>THE ACTIVE CHANGE LABORATORY Advancing Health Outcomes through Community Engagement and Optimization of Lifestyle Interventions Goal: Engage research partners at multiple levels (community member, provider, organizational leader) in the design and optimization of lifestyle interventions to improve sustained behavior change. Mission: Our mission is to help all individuals improve their health and wellbeing by changing [&hellip;]<\/p>\n","protected":false},"author":93,"featured_media":0,"parent":26222,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_eb_attr":"","_genesis_hide_title":true,"_genesis_hide_breadcrumbs":true,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-26224","page","type-page","status-publish","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Active Change Laboratory - Kinesiology, Recreation, and Sport Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cehhs.utk.edu\/krss\/research\/the-active-change-laboratory\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Active Change Laboratory - Kinesiology, Recreation, and Sport Studies\" \/>\n<meta property=\"og:description\" content=\"THE ACTIVE CHANGE LABORATORY Advancing Health Outcomes through Community Engagement and Optimization of Lifestyle Interventions Goal: Engage research partners at multiple levels (community member, provider, organizational leader) in the design and optimization of lifestyle interventions to improve sustained behavior change. 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